Overview

Associate Director, Translational Lead Respiratory at GSK. Role posted Sep 5, 2025. Site/Location: UK - Hertfordshire - Stevenage; London – New Oxford Street; USA - Pennsylvania - Upper Providence.

The Respiratory, Immunology and Inflammation Translational Unit (RIITU), within the RIIRU therapy area, is accountable for end-to-end disease-area translational science to inform therapy-area and program-level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher-confidence asset-related decisions. This includes generation of foundational data as well as disease biomarker development and validation to deploy tools/biomarkers for Proof of Mechanism (PoM), signs of clinical efficacy, Proof of Concept (PoC), and pairing Mechanisms of Action (MoAs) with patient subtypes to predict responder populations.

We offer a competitive salary, annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practices; our Performance with Choice programme offers a hybrid working model to balance remote and in-office work. For more on life at GSK, please visit our Life at GSK page.

In this role you will:

• Lead and/or contribute to developing innovative translational strategies in Respiratory for assets ranging from preclinical to clinical stage of development.
• Develop biomarker strategies aligned with clinical development plans to generate data that informs on target engagement, pharmacodynamics, mechanism of action and patient stratification/selection.
• Represent RIITU at Early Development Team (EDT), Clinical Matrix Teams (CMT) and clinical trial study teams (ST). As part of the CMT and clinical ST, establish clear decision-making criteria to enable biomarker-informed clinical decisions.
• Provide input on biomarker-related elements of clinical study documentation for study start and reporting of biomarker data generated from clinical trials.
• Provide scientific expertise and technical guidance to enable timely biomarker sample collection and analysis including high-dimensional assays to deliver high-quality biomarker data packages to inform clinical development, integrated evidence plan and regulatory strategy.
• Collaborate with cross-functional teams including biology, translational disease teams, human genetics and genomics, clinical, medical affairs to ensure end-to-end biomarker data generation for asset needs and reverse translation to support the pipeline.

Qualifications

Basic Qualifications & Skills

• Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field).
• Experience in translational science and biomarker development in a clinical trial setting within the pharmaceutical or biotechnology industry.
• Respiratory disease area knowledge and understanding in translational/biomarker development and implementation.
• Experience working in a clinical trial setting as part of a clinical study team and experience authoring/oversight of clinical and regulatory documents.
• Knowledge of regulatory requirements, industry standards, and compliance considerations in Translational Research and biomarker development and validation.
• Experience in managing external collaborations with academic partners and CROs.
• Strong interpersonal, matrix leadership and communication skills with ability to thrive in a matrix environment.

Preferred Qualifications & Skills

Please note these are preferred, not required; apply even if you do not have them:

• Demonstrated scientific capability evidenced by publications, research reports, and external presentations.
• Up-to-date knowledge and deep understanding of major molecular and genomic assay technologies and platforms.
• Experience with novel technologies such as spatial transcriptomics and AIML.

Important dates

Closing Date for Applications – 19th September 2025 (COB).

Please provide a copy of the Job Description as it will not be available post-closure. When applying, use the cover letter or CV to describe how you meet the competencies outlined in the job requirements. Information provided will be used to assess your application.

Equal Opportunity & Additional Information

GSK is an Equal Opportunity Employer. We are committed to an agile working culture and will discuss flexibility options with the hiring team. For adjustments to our process, contact UKRecruitment.Adjustments@gsk.com or 0808 234 4391. Details on how we handle adjustments are provided in our UK Recruitment FAQ guide.

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